Esketamine Treatment (Spravato)
What is esketamine (Spravato®)?
Esketamine (Spravato®) is an FDA-approved nasal spray used to treat treatment-resistant depression and depression with suicidal thoughts. It works quickly—often within hours—and is given under medical supervision in a clinic. Esketamine is used alongside an oral antidepressant and offers hope for those who haven’t responded to traditional treatments.
How is it administered?
Esketamine is a nasal spray self-administered in the clinic. Patients are monitored on-site for at least two hours after each dose.
Are there side effects?
Common side effects include dizziness, nausea, dissociation, and increased blood pressure. These are closely monitored during your visit.
How does esketamine work?
Unlike traditional antidepressants, esketamine works on the brain’s glutamate system. This helps restore connections in the brain and can lead to rapid improvement in mood.
How quickly does it work?
Many patients experience symptom relief within hours to days, though response time can vary.
Will my insurance cover it?
Many insurance plans cover esketamine treatment with prior authorization. Our team can help verify coverage and handle paperwork.
Who is eligible for esketamine treatment?
Adults who have not responded to at least two different antidepressants may qualify. A psychiatric evaluation is required to determine eligibility.
How often will I need treatment?
Treatment typically starts twice per week, then tapers to once weekly or every other week based on progress and provider recommendation.
Can I drive after treatment?
No. You must arrange transportation, as you are not allowed to drive or operate machinery until the next day.
How is esketamine different from ketamine infusions?
Esketamine is a specific, purified form of ketamine approved by the FDA for depression and delivered as a nasal spray, whereas IV ketamine is used off-label and not FDA-approved for depression.
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